Boyer L, et al. - Using the ThermoSmart system, researchers compared CPAP effectiveness and tolerance in severe obstructive sleep apnoea (OSA) patients with or without (w/o) heated humidification. CPAP-naive patients with severe OSA were included for this investigation and met one or more of the following criteria: >65 years, using >1 drying medication, previous nasal symptoms or nasal surgery. In this multicenter RCT study, patients were randomized for 1 month to CPAP w/o heated humidification and then transferred for another month to the other treatment arm. According to findings, ThermoSmart helps to reduce discomfort in the nose and throat due to CPAP therapy, these effects did not translate into better compliance, but patients preferred ThermoSmart.