Mol A, et al. - In order to confirm the assumption that orthostatic hypotension (OH) may negatively affect physical functioning and aggravate morbidities, researchers analyzed studies that reported on the association of OH with physical functioning in older adults via systematically searching MEDLINE (from 1946), PubMed (from 1966) and EMBASE databases (from 1947). They included 42 studies in the systematic review (29,421 individuals) and 29 studies in the meta-analyses (23,879 individuals). Findings revealed OH to be associated with impaired balance, activities of daily living (ADL) performance, and Hoehn and Yahr scale (HY)/Unified Parkinson’s Disease Rating Scale (UPDRS) III performance, but not with other physical functioning categories. These results suggested that some aspects of physical functioning could be enhanced by interventions targeting OH.