Ma A, et al. - Experts aspired to explore whether very low birth weight infants (VLBWs) can benefit from oropharyngeal colostrum (OC). Ventilator-associated pneumonia (VAP), necrotizing enterocolitis (NEC), bronchopulmonary dysplasia (BPD), late-onset sepsis, and death were included primary outcomes. The time of full enteral feeding and the length of stay were the included secondary outcomes. Eight randomized controlled trials involving 682 individuals (OC group: 332; non-OC group: 350) were included. According to this systematic review and meta-analysis, OC may greatly reduce the incidence of VAP, and thus its regular use for VLBWs to prevent infectious diseases should be considered.