Beeres FJP, Diwersi N, Houwert MR, et al. - In this meta-analysis, minimal-invasive plate osteosynthesis (MIPO) was compared with open reduction internal fixation (ORIF) for humeral shaft fractures regarding non-union, re-intervention, radial nerve palsy, time to union, operation duration, and functional outcomes. Researchers carried out to search PubMed/Medline/Embase/CENTRAL/CINAHL for both randomized clinical trials (RCT) and observational studies comparing MIPO with ORIF for humeral shaft fractures. They stratified a subgroup analysis by study design (RCTs and observational studies). The analysis included a total of two RCT's (98 patients) and seven observational studies (263 patients). For the treatment of humeral shaft fractures, MIPO has a lower risk for non-union than ORIF. The data demonstrate that the radial nerve palsy secondary to operation is a temporary issue resolving in all patients in both treatment groups. The general balance leans towards MIPO having more favorable outcomes, although both treatment options are viable.