Elfström KM, Eklund C, Lamin H, et al. - Implementation of organized primary HPV-based screening in a real-life screening program revealed its acceptability as well as effectiveness.

• Primary HPV-based screening or primary cytology-based screening was conducted among a total of 395,725 women aged 30 to 64 years who were invited to organized cervical screening in Stockholm, Sweden.

• Detection rate of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) was assessed as the primary outcome.

• Secondary outcomes were screening attendance and referral rates to histology. Both screening methods had comparable detection of CIN2+.

• A modestly increased attendance after new invitations and an increased rate of referral with completed biopsy were recorded among women receiving primary HPV-based screening.