Elkamshoushi AM, et al. - In the present study, the researchers tested the safety and effectiveness of oral tranexamic acid alone and combined with either topical hydroquinone 4% or low‐fluence 1064nm Q‐switched Nd:YAG laser in the treatment of mixed melasma. Study participants were randomly divided into three groups of 20 patients each. Group A received oral tranexamic acid 250 mg twice daily for 3 months; group B received tranexamic acid similarly combined with topical hydroquinone 4% cream; group C received tranexamic acid combined with 2 sessions of 1064nm low fluence Q‐switched ND:YAG laser (850‐1200 mJ/cm ², 4‐5Hz,spot size 4 mm) spaced 4 weeks apart. Melasma can be treated with oral tranexamic acid, which is a tolerable and safe treatment option. Combining hydroquinone 4% with oral tranexamic acid is linked to a relatively earlier and better cosmetic outcome.