London K, et al. - Given the effectiveness of oral sucrose in reducing procedural pain from single events (including heel lance, venepuncture and intramuscular injection) in neonates, researchers here investigated the effectiveness of oral sucrose in reducing procedural pain in children aged between 3 months and 3 years undergoing transurethral bladder catheterization (TUBC). They conducted a randomized, double-blind, placebo-controlled study including 40 participants requiring TUBC at Nepean Hospital, Sydney, Australia from June 2005 to June 2010. Random assignment of the participants to receive either 4 mL of 75% oral sucrose (n = 20) or a placebo (sterilised water) (n = 20), was done. Of the outcome measures, 65% favored the oral sucrose group, 31% favored the placebo group, and 4% detected no difference between the oral sucrose and placebo groups. Insufficient evidence was identified for the establishment of the effectiveness of oral sucrose in decreasing procedural pain in children aged between 3 months and 3 years undergoing TUBC. In line with previous studies, this work produced stronger evidence supporting the effectiveness of oral sucrose in diminishing procedural pain in neonates but not older children.