Kumar A, Gosavi RS, Sundaram V, et al. - Researchers examined whether oral paracetamol vs oral ibuprofen is non-inferior in closing hemodynamically significant patent ductus arteriosus (hsPDA) with an a priori noninferiority (NI) margin of 15%. In this multicenter, randomized, controlled, NI trial conducted in level III neonatal intensive care units, 161 inborn preterm neonates of < 32 weeks of gestation with hsPDA were randomized to receive oral paracetamol or oral ibuprofen. Outcomes revealed non-inferiority of oral paracetamol to oral ibuprofen for the closure of hsPDA in these preterm neonates. Further, there were no differences in the adverse events studied.