Bommelaer G, Laharie D, Nancey S, et al. - In this double-blind randomized controlled trial, researchers explored the effectiveness of curcumin vs placebo in patients receiving concomitant thiopurine therapy to prevent postoperative recurrence of Crohn's disease (CD) based on endoscopic and clinical indices. From October 2014 through January 2018, this trial was conducted at 8 referral centers in France. The study sample consisted of 62 consecutive patients with CD undergoing bowel resection. Study participants got azathioprine (2.5 mg/kg) and were randomly assigned to groups given oral curcumin (3 g/day, n = 31) or an identical placebo (n = 31) for 6 months and then assessed by colonoscopy. Investigators discovered that curcumin was no more effective than placebo in preventing CD recurrence in a randomized controlled trial of patients who had surgery for CD and received thiopurine treatment. No significant differences were found between groups in quality of life or severe adverse events.