Bagan J, et al. - In this investigation, researchers compared the clinical features of gingival proliferative leukoplakia (PL) patients with oral squamous cell carcinoma with and without progression. Study participants were divided into two groups: group 1 included 33 gingival PL patients who did not progress to cancer, and group 2 included 30 PL patients who developed malignant transformation during follow-up. In the gingival cancer group, female sex was predominant, and simultaneous involvement of buccal mucosa, tongue, and palate was more common in this group than in the cancer-free group. In the group of cancer patients, PL lesions were also the largest. Most gingival cancer took the form of oral ulceration in areas with teeth. In patients with PL, the simultaneous presence of lesions on the buccal mucosa, grade of lesion extension, and presence of ulcerative lesion were significantly linked to gingival cancer.