Sonneveld MJ, et al. - In this investigation, researchers studied and wanted to optimize the performance of two non-invasive indices for ruling out cirrhosis: the aspartate aminotransferase-platelet ratio index (APRI) and fibrosis score based on four factors (FIB-4). With the exception of those 30 years old or younger, subgroup analysis indicated that the new FIB-4 cutoff was acceptable in all subgroups. Due to high misclassification rates, conventional cutoffs for APRI and FIB-4 should not be used to guide patient management with chronic hepatitis B. Findings suggested that a newly identified and externally validated cutoff for FIB-4 (≤0.70) can be used in patients over 30 years of age to exclude cirrhosis.