Kildemoes RJ, Rasmussen MH, Agersø H, et al. - In the present study, the researchers sought to develop and evaluate the reliability of linear models for predicting mean and peak insulin-like growth factor-I (IGF-I) levels from samples taken on different days after dosing. They used a pharmacokinetic/pharmacodynamic model to simulate IGF-I data in adults and children following weekly somapacitan treatment of GH deficiency (GHD). Thirty-nine thousand two hundred IGF-I profiles were simulated with reference to data from 26 adults and 23 children with GHD. Linear models have provided an easy and accurate method to support optimal IGF-I monitoring by predicting mean and peak IGF-I levels based on an IGF-I sample after somapacitan dosing.