Reed CC, et al. - Authors here assess a histologic cutpoint that identifies successful treatment of eosinophilic esophagitis (EoE) by assessing symptomatic and endoscopic improvement. In this prospective study of patients with EoE, a cutpoint of <15 eos/hpf identifies most patients with symptom and endoscopic improvements, providing support for the current diagnostic threshold. A lower threshold (<5 eos/hpf) seems identifying most patients with a combination of symptom and endoscopic responses; this cutpoint could have utility in situations that require a stringent histologic.