Rahman H, et al. - In 15,434 patients with transient ischemic attack or ischemic stroke (IS), researchers determined the ideal period of effectiveness and safety of aspirin plus clopidogrel (A+C) vs aspirin monotherapy. In contrast to short-term A+C, intermediate-term and long-term A+C regimens significantly raised major bleeding risk. The results of this systematic review and meta-analysis indicate that excessive all-cause mortality was limited to long-term A+C. In patients with acute IS or transient ischemic attack, short-term A+C had higher efficacy and comparable safety vs aspirin alone, though for recurrent IS and major adverse cardiovascular events (composite of stroke, myocardial infarction, and cardiovascular mortality), long-term A+C had no beneficial effect.