Duval S, Pepe PE, Aufderheide TP, et al. - In this cohort study, researchers analyzed data from 3,643 people in the National Institutes of Health clinical trials network database to determine the optimal chest compression rate (CCR)-chest compression depth (CCD) combination—especially with respect to age, sex, presenting cardiac rhythm, and CPR adjunct use. According to findings, the combination of 107 compressions per minute and a depth of 4.7 cm was linked to significantly improved results for out-of-hospital cardiac arrest. The optimal CCR-CCD combination stayed comparable irrespective of age, sex, presenting cardiac rhythm, or CPR adjunct use.