Nakajima A, Minami Y, Araki M, et al. - The present study was performed to distinguish optical coherence tomography predictors for a favorable vascular response to statin therapy. Researchers enrolled individuals who had serial optical coherence tomography imaging at baseline and at 6 months. Using a 3‐dimensional computer‐aided algorithm, the thin‐cap area (defined as an area with fibrous cap thickness < 200 μm) was assessed, and variations in the thin‐cap area at 6 months were estimated. They defined a favorable vascular response as the highest tertile in the degree of reduction of the thin‐cap area. Macrophage index was characterized as the product of the average macrophage arc and length of the lesion with macrophage infiltration. In the analysis, 140 nonculprit lipid plaques were identified in 84 individuals. The results of this study exhibited that the three optical coherence tomography predictors for a favorable vascular response to statin therapy have been identified: large thin‐cap area, high macrophage index, and layered plaque. It was shown that favorable vascular response to statin was correlated with signs of reduced inflammation.