Zhao X, Zhang X, Lv B, et al. - The study used optical coherence tomography (OCT) images to predict short-term anti-vascular endothelial growth factor (anti-VEGF) treatment responder/non-responder for neovascular age-related macular degeneration (nAMD) patients. In total, 4,944 OCT scans from 206 patients with nAMD were involved to develop and assess a responder/non-responder prediction method for the short-term effect of anti-VEGF therapy. The proposed sensitive structure-guided network predicts the short-term efficacy of anti-VEGF treatment for nAMD patients effectively. This technique may help clinicians explain the importance of anti-VEGF treatment to potential responders while avoiding unnecessary treatment for non-responders.