Spain RI, et al. – The goal of this study is to detect optic nerve damage utilizing optical coherence tomography (OCT) and OCT angiography in multiple sclerosis (MS). MS produces both retinal structural loss and reduced optic nerve head (ONH) perfusion in MS eyes with and without the history of optic neuritis (ON). The combination of perfusion and structural measurements enhances detection of optic nerve damage in MS. OCT angiography could be a valuable additional retinal marker in the assessment of ON in MS.