Cao D, et al. - An assessment was conducted of the changes in retinal vascular plexuses and choriocapillaris in individuals with type 2 diabetes mellitus (DM2) without diabetic retinopathy (DR) and healthy controls with the aid of optical coherence tomography angiography (OCTA). Preclinical DR could be detected before the manifestation of clinically apparent retinopathy in diabetic eyes through OCTA. It was determined that DM2 patients without DR presented with superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris impairment. Hence, OCTA could serve as a promising tool for regular screening of diabetic eyes for DR.