Marta A, Malheiro L, Coelho J, et al. - In this case-control observational study, researchers compared the retinal vasculature characteristics between the eyes of patients with and without phacomatosis. Eighty eyes were included in the report. Neurofibromatosis Type 1 patients had higher central macular thickness, a lower optical disk nervous fiber layer, a lower perimeter, area, and circularity of the foveal avascular zone, a higher vascular density of macular avascular layer, and a lower papillary vascular density of superficial capillary plexus. Patients with phacomatosis demonstrated statistically important discrepancies in the features of the retinal vasculature relative to eyes without pathology. In order to determine when and if these parameters change with the course of the disease and if they can be used as biomarkers for the severity or progression of the disease, further studies are required.