Chen NN, Chen WD, Lai CH, et al. - The present study was conducted to describe a relationship between the treatment response of diabetic macular edema (DME) to intravitreal ranibizumab (IVR) injections and different morphology patterns using spectral-domain optical coherence tomography (SD-OCT). Researchers designed a retrospective study including a total of 216 eyes of 142 individuals who received IVR for DME and were observed for at least 2 years. They categorized all individuals into four groups based on the OCT findings. After long-term IVR treatment, a trend toward decreased effectiveness was observed in the DRT group. In the VMIA group, consistent IVR treatment could still achieve favorable improvement in the reduction of CMT in a 2-year follow-up. The evidence suggested that in DME, different OCT patterns may influence the therapeutic role of anti-VEGF agents and prognosticate the structured outcome.