Tilia L, et al. - Researchers examined the predictive value of oocyte meiotic spindle (OMS) morphology at intracytoplasmic sperm injection (ICSI) for blastocyst ploidy. In addition, they determined if OMS morphology may assist in standard morphology-based blastocyst selection. They performed a prospective cohort study of patients undergoing ICSI cycles with an intention to perform preimplantation genetic testing for aneuploidy (PGT-A). Classification of the morphology of 2,056 OMSs was performed. Findings support the predictive value of OMS morphology for blastocyst ploidy and that it can potentially aid standard morphology-based blastocyst selection. Compared with all other OMS types combined, normal OMS exhibited a positive association with blastocyst euploidy, per either “intention-to-treat” or an “as-treated analysis” basis. The presence of a normal OMS was robustly associated with the probability of blastocyst euploidy even after controlling for female age, blastocyst quality, and developmental stage.