Sayed KM, et al. - In this prospective comparative case series study, researchers investigated 100 patients with IgE-mediated allergic conjunctivitis (AC) to determine clinical and immunological efficacy and safety of allergen immunotherapy (AIT), as well as performed comparisons between sublingual and subcutaneous routes of administration. Patients with AC commonly developed aeroallergen polysensitization. The inclusion of skin prick test in the diagnostic workup of those patients was recommended. AIT showed the potential to provide a significant decrease in symptom and medication scores without ocular or systemic side effects, and therefore, it was viewed as a safe and effective therapy for patients with AC. With regard to attaining clinical and immunologic improvement, no significant difference was found between sublingual immunotherapy vs subcutaneous immunotherapy, and therefore, the patient can pick his preferred method for therapy.