Calaway AC, et al. - Between 1980 and 2018, 14 cases with a median age of 44.2 years were retrospectively studied to assess the clinical history of subjects with clinical stage II sex cord-stromal tumors who underwent Retroperitoneal Lymph Node Dissection (RPLND). Authors recorded 4 candidates with clinical stage II disease whereas 10 subjects developed metastatic disease during follow-up of initial clinical stage I disease with a median time to metastasis of 2.7 years. Among those 10 cases with orchiectomy pathology data available, at least 1 risk factor on testis pathology was also noted. They observed that metastatic sex cord-stromal tumors were rare and more resistant to standard treatment modalities as compared to metastatic germ cell tumors.