Reynolds MM, et al. - This article was written with the objective to investigate the types and frequency of ocular manifestations in transthyretin (TTR) amyloidosis were presented. In this large cohort of patients with TTR amyloidosis, female sex and reduced visual acuity (VA) were related to ocular amyloid. Three mutations which have not been previously reported to have vitreous involvement were depicted: Glu89Lys, Gly47Arg, and homozygous Gly6Ser.