Schwering MS, et al. - Given human immunodeficiency virus-infected patients on nevirapine-based antiretroviral therapy and/or cotrimoxazole commonly exhibit manifestations of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in Sub-Saharan Africa, and severe ocular complications resulting in moderate to severe visual impairment or blindness are commonly faced by these patients, therefore, researchers performed this literature review, illustrated by retrospective hospital-based case series. Following the diagnosis of SJS/TEN, patients (n = 8) at Lions Sight First Eye Hospital, Blantyre, Malawi, who developed severe ocular complications were illustrated. In Sub Saharan Africa, a significant correlation of SJS/TEN with moderate visual impairment up to blindness was evident. The importance of early identification of eye complications and engagement of ophthalmologists in the acute stage, early management with local steroids, and close monitoring for up to 6 months following the acute phase was highlighted. In dark skin phototype, severe ocular complications appeared to be more severe.