OCT structural abnormality detection in glaucoma using topographically correspondent rim and retinal nerve fiber layer criteria
American Journal of Ophthalmology Jan 08, 2020
Yang H, Luo H, Hardin C, et al. - In this retrospective cross-sectional study, researchers assessed the ability of topographically correspondent (TC) minimum rim width (MRW) and peripapillary retinal nerve fiber layer thickness (pRNFLT) criteria to identify optical coherence tomography (OCT) structural abnormality in glaucoma (GL) and glaucoma suspect (GLS) eyes. One hundred ninety-six GL, 150 GLS eyes, and 303 healthy eyes had PRNFL and 24 radial optic nerve head OCT imaging and manual correction of the internal limiting membrane, Bruch’s membrane opening (BMO) and outer pRNFL segmentations. According to results, the best performing criteria were the TC sectoral criteria (1 GH MRW + corresponding GH RNFLT), (1 30° MRW + any 1 corresponding or adjacent 30° pRNFLT), 30⁰ and GH comMR and global comMR, showing: (96-99% specificity); 86-91% sensitivity for GL; 80-84% sensitivity for early GL (MD ≥ -4.0 dB) and 93-96% sensitivity for moderate-to-advanced GL (MD < -4.0 dB). In GL eyes with high diagnostic precision, clinically intuitive TC MRW and pRNFLT combination criteria identified the sectoral location of OCT abnormality.
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