Pahl DA, et al. – This study was performed to ascertain whether ultra–widefield fluorescein angiography (UWFA), spectral–domain optical coherence tomography (SD–OCT) and optical coherence tomography angiography (OCT–A) detect more frequent retinopathy in adolescents with sickle cell disease (SCD). According to the outcome obtained, all 24 eyes with sufficient ultra–widefield fluorescein angiography (UWFA) studies exhibited sickle retinopathy. SD–OCT and OCT–A, which have not been previously reported in the adolescent population, detected abnormal macular thinning and flow abnormalities undetected by biomicroscopy. These outcomes recommend that pediatric sickle retinopathy may be more prevalent than previously suspected. If these findings are affirmed with larger cross–sectional and prospective analyses, these approaches may enhance early screening for sickle retinopathy.