Borrelli E, Battista M, Sacconi R, et al. - Researchers conducted this retrospective cohort study to evaluate the relationship of demographics, clinical features and structural optical coherence tomography (OCT) findings to the development of sight-threatening macular complications (choroidal neovascularization [CNV], large areas of retinal pigment epithelium atrophy and cystoid macular degeneration) in a cohort of eyes with “resolved” chronic central serous chorioretinopathy (CSC) at inclusion (study baseline). In total, 71 candidates (71 eyes) with “resolved” (absence of subretinal fluid) chronic CSC at baseline and 3 years (36 months) of regular follow-ups were retrospectively recruited. Several factors were correlated with an increased risk of CNV developing: intraretinal hyperreflective foci had an HR of 11.58; inner choroidal attenuation had an HR of 9.66; the presence of macular complications in the fellow eye had an HR of 20.17. OCT risk factors for the development of macular complications in the eye with chronic CSC have been reported. The results can help to identify high-risk patients.