Wu D, et al. – In this research work, the scientists examined the role of ovarian carcinoma immunoreactive antigen–like protein 2 (OCIAD2) in hepatocellular carcinoma (HCC) progression. Their investigations revealed that reduced expression of OCIAD2 by DNA hypermethylation plays an important role in HCC tumor growth and invasion. In addition, hypermethylation of OCIAD2 probably contributes to HCC treatment development.