Beberashvili I, Ptashkin E, Azar A, et al. - In this prospective observational case series study, researchers sought to examine the potential role of obestatin, a physiological opponent of acylated ghrelin, in dietary intake regulation by analyzing the response to a meal in maintenance hemodialysis (MHD) individuals. In 21 MHD patients (aged 69.2 ± 13.1 years, 10 women, with a body mass index 27.2 ± 5.5 kg/m²), the response of obestatin to a fixed calorie meal (500 kcal) was examined. The levels of obestatin do not change acutely with the administration of food in MHD patients but correlate with changes in fullness sensation. This supports the possible role of obestatin in the long-term appetite regulation in patients with MHD.