Xu J, et al. - In this investigation involving 1,227 participants, researchers studied the role of insulin resistance as a potential contributor to the association between body mass index and stroke outcomes. The Abnormal Glucose Regulation in Patients With Acute Stroke Across-China registry included patients with ischemic stroke but not diabetes mellitus. Significant interactions were noted between body mass index and homeostasis model assessment–insulin resistance with respect to the risks of mortality and poor functional outcome. Investigators observed the mortality-obesity paradox and functional outcome in patients with insulin resistance, but did not observe the paradox of obesity in patients with insulin sensitivity. Overall, they concluded that insulin resistance may be one of the mechanisms underlying the obesity paradox of the outcome in patients with ischemic stroke.