Nyambuya TM, Dludla PV, Mxinwa V, et al. - Researchers ascertained how obesity could impact T-helper (T_H)1 (tumor necrosis factor α, interferon gamma, interleukin (IL)-6, IL-8) and T_H2 (IL-4, IL-5, IL-10, IL-13) immune responses in children suffering from asthma. They explored MEDLINE and gray literature electronic databases and identified eligible studies from inception up until April 2020. In total, 5 eligible studies with 482 participants were included. They found lean people with asthma, vs controls without asthma, showed an increased T_H2-mediated immune response. Findings revealed disparities in immune responses mediated by T-helper cells in lean and obese children experiencing asthma. Moreover, and not specific to asthma, obesity polarized the immune response toward T _H1 instead of the classical T _H2.