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Obesity increases the incidence of new-onset lupus nephritis and organ damage during follow-up in patients with systemic lupus erythematosus

Lupus Apr 29, 2020

Kang JH, Xu H, Choi SE, et al. - Among Korean patients with systemic lupus erythematosus (SLE) (n = 393), researchers undertook this inquiry to determine how clinical manifestations, disease activity and organ damage in these patients could be influenced by the presence of obesity. They analyzed demographic data, clinical manifestations, laboratory results and Physician Global Assessment, Systemic Lupus Erythematosus Disease Activity Index-2000 and Systemic Lupus International Collaborating Clinics damage index scores, to evaluate the patients yearly for three consecutive years. Based on body mass index (BMI), the patients were categorized: normal weight, BMI <23 kg/m2; overweight, 23 kg/m2 ≤BMI <25 kg/m2; obese, BMI ≥25 kg/m2. Findings revealed higher incidences of newly developed nephritis and cumulative organ damage in obese SLE patients compared with non-obese SLE patients.

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