Kim Y, et al. - In young and middle-aged adults with nonalcoholic fatty liver disease (NAFLD), researchers assessed the association of weight change and baseline BMI with fibrosis progression, determined by non-invasive measurement of a marker. In this prospective cohort study, they included 40,700 adults with NAFLD in Korea who had regular health screening exams and were followed for a median 6.0 years. Based on aspartate aminotransferase to platelet ratio index, obesity and weight gain were independently correlated with increased risk of fibrosis progression. In individuals with NAFLD, sustaining a normal healthy weight and avoiding weight gain could help reduce fibrosis progression.