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Obesity and risk of differentiated thyroid cancer: A large-scale case-control study

Clinical Endocrinology Sep 11, 2019

He Q, et al. – Researchers performed a large frequency-matched case-control study based on hospital data to assess the association of anthropometric measurements with the risk of differentiated thyroid cancer (DTC). The study sample consisted of 10,668 patients with DTC as well as 11,858 controls. According to univariate analysis, a significant increase in DTC risk with increased height, weight, BMI, body surface area (BSA), and body fat percentage (BF%), were noted. In addition, the multivariate analysis demonstrated a positive correlation. Investigators found that BF% remained significant only for women under 50 years of age; however, for both sexes over age 50, neither BSA nor BF% was significantly linked to DTC risk. The risk of DTC, which was potentially affected by age and sex, was positively associated with BMI, BSA, and BF%. BF%, but not BMI, displayed a significant relationship with DTC risk for men under age 50.

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