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Nutritional status according to the Mini Nutritional Assessment (MNA) as potential prognostic factor for health and treatment outcomes in patients with cancer: A systematic review

BMC Cancer Jul 01, 2020

Torbahn G, Strauss T, Sieber CC, et al. - Given that cancer patients carry an increased risk of malnutrition which is related to poor result, and that the Mini Nutritional Assessment (MNA) is commonly employed in older patients with cancer but its link with outcome is unknown, so researchers addressed this topic by analyzing studies relating MNA-results with any reported outcome. They analyzed 56 studies identified from four databases. Multivariable analyses revealed that a higher likelihood for death/poor overall survival (22/27 studies), shorter progression-free survival/time to progression (3/5 studies), treatment maintenance (5/8 studies) and (health-related) quality of life (2/2 studies), but not for treatment toxicity/complications (1/7 studies) or functional status/decline (1/3 studies), was significantly predicted by (risk of) malnutrition evaluated by MNA. Overall, death/survival, cancer advancement, treatment maintenance and (health-related) quality of life, but not adverse treatment results and functional status/ decline, were predicted by MNA-result in cancer patients. Results were less clear for other outcomes. Moderate to high risk of bias was also reported.

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