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Nuclear pseudoinclusions in melanoma cells: Prognostic fact or artifact? The possible role of Golgi phosphoprotein 3 overexpression in nuclear pseudoinclusions generation

Pathology International Feb 02, 2018

Donizy P, et al. - Nuclear pseudoinclusions (NPIs) are classically found in papillary thyroid carcinoma and meningioma. This study was designed to analyze the potential link between NPIs and other clinicopathological characteristics of melanoma. Findings suggested that NPIs are not an uncommon finding in skin melanoma. Furthermore, owing to their diagnostic and prognostic utility, NPIs could be helpful in the daily routine histopathological practice. The possible explanation of NPI generation is associated with enhanced activity of Golgi apparatus in melanoma cells.
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