Marioni G, et al. - Authors assessed 62 subjects to examine the associated role of nuclear onco-suppressors maspin and nm23-H1 (a metastasis suppressor) in laryngeal squamous cell carcinoma (LSCC). They observed a lower recurrence rate in subjects with a nuclear maspin pattern of expression. Nuclear nm23-H1 expression was significantly lower in cases who encountered disease recurrence. They observed a significantly longer disease-free survival (DFS) in candidates with maspin nuclear pattern or with nuclear nm23-H1 expression ≥10%. They suggested that re-activation of maspin functions would probably help in the treatment of advanced LSCC.