Zuzarte P, et al. - Since an independent link has been shown between reduced ejection fraction (EF) and increased N-terminal-prohormone B-type natriuretic peptide (NT-proBNP) with depressive symptoms, researchers investigated if, in patients with heart failure (HF), NT-proBNP mediated the impact of reduced EF on depressive and anxiety symptoms. As per findings, NT-proBNP is suggested to be a potential mechanism linking reduced EF and depressive symptoms in patients with HF. Preliminary results suggest that HF patients with reduced EF at high risk for depression, disease progression, and mortality could be identified via NT-proBNP.