Chen LY, et al. - Given that liver metastasis is the main cause of death in patients with colorectal cancer (CRC), researchers searched for CRC metastasis associated circular RNA, in a mouse model of liver metastasis of CRC by using RNA (transcriptome)-sequencing. A novel and conserved circular RNA, circ-NSD2, functioning as a promoter of CRC metastasis were identified. Data reported that circ-NSD2 expression was elevated in CRC tissues and was markedly increased in advanced stages or metastatic tumour of CRC patients. The findings highlighted a novel oncogenic function of circ-NSD2 and uncover a key mechanism for the circ-NSD2/miR-199b-5p/DDR1/JAG1 axis in CRC metastasis, which might serve as a prognostic factor and therapeutic target for anti-metastatic therapy in patients with colorectal metastasis.