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Novel biochemical markers of glycemia to predict pregnancy outcomes in women with type 1 diabetes

Diabetes Care Jan 29, 2021

Meek CL, Tundidor D, Feig DS, et al. - As controversies remain concerning the optimal method of monitoring glycemia in pregnant women with type 1 diabetes, researchers sought to compare the predictive performance of HbA1c, continuous glucose monitoring (CGM) metrics, and alternative biochemical markers of glycemia in predicting obstetric and neonatal outcomes. This prespecified secondary analysis was performed including 157 women from the CGM in Pregnant Women With Type 1 Diabetes Trial (CONCEPTT). Obstetric and neonatal outcomes at 24 weeks’ were noted to be significantly linked with gestation HbA1c, CGM metrics, and alternative laboratory markers. Findings still suggest the importance of HbA1c as a biomarker for obstetric and neonatal outcomes in type 1 diabetes pregnancy. No substantial improvement in the prediction of pregnancy outcomes was observed in correlation with using alternative biochemical markers of glycemia and other CGM metrics compared with widely available HbA1c and increasingly available CGM metrics (TIR and TAR).

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