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Normocalcemic and normohormonal primary hyperparathyroidism: laboratory values and end-organ effects

Otolaryngology-Head & Neck Surgery Jan 23, 2021

Hollowoa BR, et al. - As the diagnosis of classic primary hyperparathyroidism (pHPT) can be confused by variants of pHPT, described as normocalcemic (NC) and normohormonal (NH), researchers performed this analysis to compare NCpHPT and NHpHPT with classic pHPT. They conducted a MEDLINE search for variants of pHPT using the PubMed database (last queried October 2019). The search yielded 189 articles; in addition, 27 studies were identified and included for a total of 216. Findings suggest that nephrolithiasis was 21.7% (NCpHPT), 15.9% (classic pHPT), and 25.4% (NHpHPT) and reduced bone mineral density was 49.7% (NCpHPT), 39.7% (classic pHPT), and 40.3% (NHpHPT). They noted no significant differences in fractures in the NCpHPT group from the classic pHPT. Relative to classic pHPT, significantly less hypertension was reported in the NCpHPT group.

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