Ma Q, Liao X, Shao C, et al. - Researchers performed this single-center retrospective cohort study to explore the correlations of decreased alanine aminotransferase (ALT) and γ-glutamyl transferase (GGT) levels and improvements in metabolic disturbances during the routine treatment of nonalcoholic fatty liver disease (NAFLD) over time, as well as to compare the characteristics of patients with NAFLD who presented inconsistent decreases in ALT and GGT levels. This investigation was carried out in the NAFLD clinic of the First Affiliated Hospital of Sun Yat-sen University, China, from January 1, 2011, to December 31, 2019. In total, 1,048 patients (744 male and 304 female) with NAFLD were involved in this investigation. GGT normalization rate was lower in NAFLD patients with concurrently increased ALT and GGT levels, rather than ALT. Weight control and insulin resistance were both reliable predictors of GGT normalization.