Geng C, et al. - Researchers conducted an experimental study in a rat model to ascertain the protective effects of nonsteroidal anti-inflammatory drugs on post-ERCP pancreatitis. Further, they investigated underlying mechanisms. They divided 32 female rats were equally and randomly into 4 groups: the sham group, post-ERCP pancreatitis (PEP) model group, indomethacin-pretreated group, and parecoxib-pretreated group. They delivered indomethacin or parecoxib 30 minutes prior to surgery; they sacrificed the rats 24 hours after PEP establishment. They performed quantification and analysis of serum amylase and lipase activities, inflammatory cytokine release, pancreatic histopathological scores, neutrophil infiltration, the expression pattern cyclooxygenase at the protein level and pancreatic apoptosis. Outcomes revealed the protective effects of both selective and nonselective nonsteroidal anti-inflammatory drugs against post-ERCP pancreatitis; the two drugs exerted the effect by restricting inflammation and diminishing acinar cell apoptosis through the inhibition of cyclooxygenase 2.