Torabi SJ, et al. - In this retrospective analysis of the National Cancer Database (2004–2014), researchers examined the incidence and clinical profile of nonsquamous cell (non-SCC) laryngeal carcinomas and investigated the impact of surgery on survival. Eight hundred seventy-eight cases of non-SCC laryngeal cancers were identified, representing 1.02% of all malignant laryngeal cancers. Multivariate analyses revealed that surgery was significantly linked to improved survival. The specific surgical method (ie, local excision vs partial vs total laryngectomy) had no effect on survival. According to results, about 1% of all malignant laryngeal cancers originate from non-SCC. Neuroendocrine tumors currently have the highest rate of distant metastasis and the worst non-SCC cancer prognosis. As part of their treatment regimen, many non-SCC patients underwent surgery.