Kastora SL, Osborne LL, Jardine R, et al. - Researchers investigated if exposure to NSAIDs, and their sub-categories, correlates with an increased risk of anastomotic leak (AL) in colonic anastomoses among colorectal cancer patients. In addition, they examined if this affects specific anastomotic sites. By performing a systematic search of MEDLINE, Cochrane Library, ClinicalTrials.gov, Web of Science, Science Direct, Google Scholar, 15 studies involving 25,395 patients were identified for inclusion in the systematic review and meta-analysis. In the non-specific NSAID-exposed population, colocolic anastomoses were noted to be statistically more prone to AL events. Male gender was an independent confounder increasing AL rate; this was observed regardless of NSAID exposure.