Kim JI, et al. – The physicians conducted this work to determine the negative predictive value (NPV) of non–specific benign results from cone–beam CT (CBCT)–guided transthoracic core–needle biopsy (TTNB) and identify predicting factors for false–negative for malignancies. They observed 89.4% as the NPV of the non–specific benign biopsy. It was showed that PSN was a significant positive indicator, but a biopsy result of ‘granulomatous inflammation’ and exact location of needle tip within targets were significant negative indicators for false–negatives.