Karalexi MA, et al. - A systematic analysis and quantitative synthesis were conducted of the literature regarding the correlation of consumption of non-nutritive sweeteners (NNS) during childhood with negative metabolic health outcomes following the PRISMA guidelines. No connection was discovered between NNS intake during childhood with fat mass accumulation and waist circumference and a small. However, statistically prominent link with body mass index (BMI) increase was found. The associations were revealed to be positive yet marginally significant in subanalyses by sex.