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Non-malignant late cutaneous changes after allogeneic hematopoietic stem cell transplant in children

Journal of the American Academy of Dermatology Mar 30, 2018

Huang JT, et al. - Late cutaneous changes (including autoimmune conditions and permanent alopecia) and associated risk factors after allogeneic hematopoietic stem cell transplantation (HSCT) in children were characterized. They noted the factors significantly related to vitiligo to include a history of chronic graft-versus-host disease (cGVHD), transplant indication of primary immunodeficiency, and younger age at transplant. cGVHD, busulfan conditioning, and family history of early male pattern alopecia were seen to be factors significantly associated with alopecia. The risk of developing non-malignant late cutaneous changes was thus seen in pediatric HSCT recipients, particularly those with graft-versus-host disease (cGVHD).
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